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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are often described by their focus on practical aspects of study design, including recruitment and consent, adherence and the use routinely available equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which employed various investigators and participants from different geographical regions. This kind of heterogeneity is required for pragmatic trials to be valid, and it also helps reduce the chance of bias in the results. Too much heterogeneity, however can result in problems with the trial design.

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The aim of pragmatic trials is to mimic real-life scenarios and gain the highest level of validity externally. They are typically commissioned by policy makers and practitioners to inform their decision making. They can also be used to assess the cause-effect relationship of an intervention and its results. However, they shouldn't be used in lieu for the use of explanation studies.

The concept of pragmatism is controversial, and there are questions about whether pragmatic trials can replace tests for 프라그마틱 홈페이지 슬롯 (https://pragmatic-Korea77531.ourcodeblog.com) explanations or if they should be a complement to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate the validity of a clinical or physiological hypothesis, and pragmatic trials, which guide the practice and policy decisions. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the elements of a practical study, including the recruitment, design, and delivery of the intervention and follow-up.

There is a positive trend in the number of pragmatic trials that are published. A recent Medline query that used the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This indicates that the health science community is becoming more sensitive to the subject of pragmatic thinking. It is important to keep in mind, however, that the majority were conducted in primary-care settings.